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Research Spending & Results

Award Detail

Awardee:WASHINGTON STATE UNIVERSITY
Doing Business As Name:Washington State University
PD/PI:
  • Peter Reilly
  • (509) 335-0042
  • pete.reilly@wsu.edu
Award Date:06/17/2021
Estimated Total Award Amount: $ 526,214
Funds Obligated to Date: $ 526,214
  • FY 2021=$526,214
Start Date:07/01/2021
End Date:06/30/2024
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.049
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:Instrument Development: A New Digitally Driven Triple Quadrupole Mass Spectrometer
Federal Award ID Number:2103645
DUNS ID:041485301
Parent DUNS ID:041485301
Program:Chemical Measurement & Imaging
Program Officer:
  • Kelsey Cook
  • (703) 292-7490
  • kcook@nsf.gov

Awardee Location

Street:280 Lighty
City:PULLMAN
State:WA
ZIP:99164-1060
County:Pullman
Country:US
Awardee Cong. District:05

Primary Place of Performance

Organization Name:Washington State University
Street:Fulmer 305
City:PULLMAN
State:WA
ZIP:99164-4630
County:Pullman
Country:US
Cong. District:05

Abstract at Time of Award

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Peter Reilly and his group at Washington State University are devising and enhancing methods of biological and chemical analysis by converting an important method of analysis called “mass spectrometry” from analog to digital operation. The aim is to expand applicability and to enhance the quality of results, comparable to the improvements derived from the conversion of telephones from analog to digital. The project focuses on a type of instrument called a triple quadrupole mass spectrometer that is routinely used in hospitals and medical laboratories to perform diagnostic tests. The digital conversion seeks to expand the number and types of tests that can be performed by enhancing the instrument’s speed, resolution, mass range, and sensitivity. Beyond the important scientific goals of this proposal, the training of highly skilled instrumentation scientists is an emerging national need that will be addressed by this effort and the collaborations that will result. The Reilly group has invented a new digital waveform generation method that they recently used to develop a digital mass filter. Relative to a conventional analog analyzer (i.e., sine), the digital filter can operate in higher stability zones without loss of mass range, providing significantly better sensitivity, resolution, and speed of analysis compared to commercial counterparts. They are now using the digital waveform technology to create a digital triple quadrupole mass spectrometer (DQ3MS) both to outperform commercial instruments (Q3MS) both by improving performance at m/z (mass:charge ratio) < 3000 (accessible by Q3MS) and extending the accessible m/z range. This should substantially expand the range and types of biological molecules that can be analyzed by tandem mass spectrometry (MS/MS). The development of instrumentation with increased mass range is needed to directly and rapidly measure and quantify the distribution of expressed proteins, analyze complexes and their interactions. Digitally driven mass spectrometers are expected to increase the rate of discovery in the biology-based sciences. The anticipated benefits arising from the proposed work include: 1) training and education of future scientists in the area of analytical chemistry and biological mass spectrometry, 2) changing the paradigm for analyzing biological molecules and particles by mass spectrometry, and 3) establishing the area of analytical biology by rapidly quantifying biomolecules, their interactions and processes. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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