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Exposing the architecture of a molecular machine

NSF Award:

High Resolution Structural and Functional Mapping on Mediator of Transcriptional Regulation  (Indiana University)

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A series of molecular machines control many important cellular processes such as transcription (the first step in gene expression) and DNA replication. The machines are often made of many proteins that function together in groups. These multi-protein complexes have very precise architectures that the proteins need to carry out their essential functions. One of the protein complexes, the Mediator, controls when genes turn on and off, but little was known about its architecture.

Now, a team led by Yuichiro Takagi of Indiana University School of Medicine has deciphered the unique structure of an essential part of Mediator. The researchers demonstrated how this complex molecular machine is built from each of its components and how its unique architecture enables a molecular machine to regulate the cellular process that translates genetic information into proteins and processes of life.


  • researchers determined an essential structure of a molecular machine that regulates dna
Researchers have determined the structure of an essential part of a molecular machine that helps regulate DNA.
Yuichiro Takagi, Indiana University School of Medicine

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