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Optical imaging advances nanomaterials and nanotherapeutics

NSF Award:

RII: Enhancing Alabama's Research Capacity in Nano/Bio Science and Sensors  (Tuskegee University)

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Advanced optical and optoacoustic imaging technology is now available to the bio-nanoscience community through the Auburn Laboratory for Imaging Animal Systems (ALIAS) at the Auburn University (AU) College of Veterinary Medicine. The resource provides support to investigators statewide who are studying complex bio-nanotechnological questions involving small animal models.

Research to understand how microorganisms, biological and nanoengineered materials interact with and affect living tissues will benefit from the ALIAS technology, which includes in vivo bioluminescence, fluorescence and radiologic imaging modalities, as well as multispectral imaging and multispectral optoacoustic tomography (MSOT).

The real-time, optical and optoacoustic imaging resource will enable dynamic 2-D and 3-D monitoring of basic anatomical, functional, molecular and kinetic information in living animals. Moreover, MSOT enables deep tissue imaging of pharmacokinetics, as well as the biodistribution of a host of bio-nanomaterials in vivo.

Only the fifth such installation of this technology in the U.S., the ALIAS facility will provide unparalleled capacity for 3-D, quantitative imaging. Images generated using ALIAS tools will provide data required to establish proof of principle and safety of novel nanomaterials and nanotherapeutics.

ALIAS is a cooperative effort between faculty associated with AU's bio-nanotechnology thrust and NSF's Experimental Program to Stimulate Cooperative Researach (EPSCoR).

 

Image

  • optical imaging reveals bioluminescent signals in a specimen
Optical imaging reveals bioluminescent signals in a specimen.
Peter Panizzi and Frank Bartol, Auburn University

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