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Research Spending & Results

Award Detail

Awardee:WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
Doing Business As Name:West Virginia University Research Corporation
PD/PI:
  • Matthew J Dietz
  • (304) 293-2970
  • mdietz@hsc.wvu.edu
Award Date:09/10/2020
Estimated Total Award Amount: $ 50,000
Funds Obligated to Date: $ 50,000
  • FY 2020=$50,000
Start Date:08/01/2020
End Date:01/31/2022
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.041
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:I-Corps: Drug delivery device for treatment of prosthetic joint infection
Federal Award ID Number:2042632
DUNS ID:191510239
Program:I-Corps
Program Officer:
  • Ruth Shuman
  • (703) 292-2160
  • rshuman@nsf.gov

Awardee Location

Street:P.O. Box 6845
City:Morgantown
State:WV
ZIP:26506-6845
County:Morgantown
Country:US
Awardee Cong. District:01

Primary Place of Performance

Organization Name:West Virginia University
Street:64 Medical Center Drive, Room 39
City:Morgantown
State:WV
ZIP:26506-9196
County:Morgantown
Country:US
Cong. District:01

Abstract at Time of Award

The broader impact/commercial potential of this I-Corps project is the development of a drug delivery system for use in joint replacement surgery and in trauma applications, spine infections, and ankle and shoulder replacements. Joint replacements are successful but occasionally complicated by postoperative infections, as are other orthopaedic procedures. The proposed technology will deliver antibiotics to those surgical sites to reduce infections. The technology will allow antibiotic concentrations to be maintained at higher levels for longer periods of time, which may shorten treatment durations currently leaving patients without a hip or knee for months at a time. This I-Corps project is based on the development of a drug delivery system to treat post-operative joint infections (PJI) for conditions including joint arthroplasties/ The current treatment algorithm for the treatment of postoperative joint infections requires intravenous antibiotics along with surgery to debride the area and deliver antimicrobials locally. Traditionally, this includes the delivery of antimicrobials through the use of bone cement, polymethylmethacrylate (PMMA). Antimicrobials delivered in this fashion reach minimum inhibitory concentrations (MIC); however, the primary culprit causing persistent PJI is often bacterial biofilm. The ability to adequately treat and eradicate biofilm-related infections requires an antibiotic concentration known as the minimum bacterial eradication concentration (MBEC), which is 100-1000 times greater in concentration than the MIC. Current drug delivery is limited to a burst elution pattern, with limited duration at the MIC and cannot be modified once surgery is complete. The proposed technology seeks to improve drug delivery to allow higher levels of local delivery that may be increased or changed as culture results warrant. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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