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Research Spending & Results

Award Detail

Awardee:UNIVERSITY OF ARKANSAS SYSTEM
Doing Business As Name:University of Arkansas
PD/PI:
  • Shannon L Servoss
  • (479) 575-4502
  • sservoss@uark.edu
Award Date:06/03/2021
Estimated Total Award Amount: $ 50,000
Funds Obligated to Date: $ 50,000
  • FY 2021=$50,000
Start Date:06/01/2021
End Date:11/30/2021
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.041
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:I-Corps: Peptoid microsphere-coated surfaces for use in treatment of wound healing
Federal Award ID Number:2130131
DUNS ID:191429745
Parent DUNS ID:055600001
Program:I-Corps
Program Officer:
  • Ruth Shuman
  • (703) 292-2160
  • rshuman@nsf.gov

Awardee Location

Street:1125 W. Maple Street
City:Fayetteville
State:AR
ZIP:72702-3124
County:Fayetteville
Country:US
Awardee Cong. District:03

Primary Place of Performance

Organization Name:University of Arkansas
Street:800 W Dickson St, 3202 Bell Engi
City:Fayetteville
State:AR
ZIP:72701-4033
County:Fayetteville
Country:US
Cong. District:03

Abstract at Time of Award

The broader impact/commercial potential of this I-Corps project is the development of an artificial extracellular matrix (aECM) for the treatment of traumatic injuries and wound healing. The proposed material may lead to more effective scaffolds and may be crafted to attach to any given substrate. Complex aECM microspheres may be inserted into a hydrogel-type design or attached to a larger structure, depending on the application. This proposed technology may reduce permanent secondary injuries commonly caused by traumatic injuries by providing stability to the damaged region. In addition, the use of an aECM in tandem with cell transplantation may encourage cell-to-cell interactions and ensure that the cell death that occurs post primary impact is minimized. If successful, the proposed materials may decrease patient recovery time and decrease cognitive loss in neuronal applications. This I-Corps project is based on the development of peptoid microspheres to create an artificial extracellular matrix (aECM) to support growth of cells. A peptoid design with alternating charged and aromatic side chains allows for the self-assembly of microspheres via pi-stacking with diameters ranging from 1.5-3.5 microns in size. The microspheres are resistant to proteolysis making them more durable in vivo than peptide counterparts. Peptoid microspheres are suitable for use in aseptic conditions, as the spheres form in an 80% ethanol solution and sustain no structural deformities when exposed to ultraviolet-sterilization. The microspheres have been tested for toxicity with multiple cell types and have proven to be nontoxic. In addition, in previous studies the topographical features have influenced the differentiation of neural stem cells to neurons and it was observed that cells arrange differently when the spheres are present in media. The versatility of this structure and promising initial results suggest that these microspheres incorporated into an artificial extracellular matrix may have applications in traumatic injury repair and wound healing. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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