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Minimize RSR Award Detail

Research Spending & Results

Award Detail

Awardee:MARSHALL UNIVERSITY RESEARCH CORPORATION
Doing Business As Name:Marshall University Research Corporation
PD/PI:
  • John Rakus
  • (304) 696-4837
  • rakus@marshall.edu
Award Date:09/12/2017
Estimated Total Award Amount: $ 160,614
Funds Obligated to Date: $ 160,614
  • FY 2017=$160,614
Start Date:09/01/2017
End Date:08/31/2019
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.083
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:RII Track-4: Characterization of LPS-induced Hsc70 ligands as a means of defining the role of C-linked glycosylation in innate immunity.
Federal Award ID Number:1738707
DUNS ID:036156615
Parent DUNS ID:036156615
Program:RESEARCH INFRASTRUCTURE IMPROV
Program Officer:
  • Raffaella Montelli
  • (703) 292-2421
  • rmontell@nsf.gov

Awardee Location

Street:One John Marshall Dr.
City:Huntington
State:WV
ZIP:25755-0002
County:Huntington
Country:US
Awardee Cong. District:03

Primary Place of Performance

Organization Name:Marshall University
Street:1 John Marshall Drive, Chemistry
City:Huntington
State:WV
ZIP:25755-8200
County:Huntington
Country:US
Cong. District:03

Abstract at Time of Award

Non-technical Description The immune system's response to infection and autoimmune diseases includes inflammation that is controlled by specific chemicals, and the production and function of many of which is not clearly understood. This project supports the PI for a six-month period in the Complex Carbohydrate Research Center (CCRC) at the University of Georgia. The CCRC possesses unparalleled research expertise and analytical instrumentation focused on the biochemical study of carbohydrate molecules, including those involved in inflammation. This fellowship allows the PI access to the expertise and the advanced instrumentation capability of CCRC, and he will bring that expertise back to Marshall University. Characterization of these molecules in the context of inflammation will provide important information about the causes and control of inflammation, including inflammation involved in autoimmune disease. Technical Description This fellowship will aid in bolstering the research capacity in West Virginia by supporting the PI's efforts to use the resources at the CCRC to evaluate protein regulators of the innate immune response. Providing access to the facilities and expertise at the CCRC will enable the PI to establish a vibrant research program studying the role of glycosylation in inflammation in West Virginia. It has been shown that C-glycosylated peptides enhance the production of the proinflammatory cytokine TNFα, secreted from lipopolysaccharide (LPS)-stimulated macrophage-like cells. This indicates that a currently unknown regulatory mechanism involving C-linked glycosylation is crucial for activation of the LPS/TLR4 pathway. As TNFα is the central cytokine produced in the inflammatory response, defining how C-linked glycosylation regulates this cytokine response is critical in properly addressing its dysregulation. Dysregulation of TNFα is inherent to inflammatory diseases such as Crohn?s disease, sepsis, rheumatoid arthritis, and metabolic syndrome.

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