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Research Spending & Results

Award Detail

Awardee:UNIVERSITY OF WASHINGTON
Doing Business As Name:University of Washington
PD/PI:
  • Karen I Goldberg
  • (215) 573-6756
  • kig@sas.upenn.edu
Award Date:07/24/2007
Estimated Total Award Amount: $ 15,000,000
Funds Obligated to Date: $ 15,605,651
  • FY 2012=$148,680
  • FY 2007=$3,000,000
  • FY 2008=$3,000,000
  • FY 2009=$3,365,458
  • FY 2010=$3,000,000
  • FY 2011=$3,091,513
Start Date:08/01/2007
End Date:07/31/2013
Transaction Type: Cooperative Agreements
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.049
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:Center for Enabling New Technologies through Catalysis
Federal Award ID Number:0650456
DUNS ID:605799469
Parent DUNS ID:042803536
Program:CHE CENTERS
Program Officer:
  • Katharine Covert
  • (703) 292-4950
  • kcovert@nsf.gov

Awardee Location

Street:4333 Brooklyn Ave NE
City:Seattle
State:WA
ZIP:98195-0001
County:Seattle
Country:US
Awardee Cong. District:07

Primary Place of Performance

Organization Name:University of Washington
Street:4333 Brooklyn Ave NE
City:Seattle
State:WA
ZIP:98195-0001
County:Seattle
Country:US
Cong. District:07

Abstract at Time of Award

The Center for Enabling New Technologies through Catalysis, or CENTC, led by the University of Washington, is supported by an award from the NSF Division of Chemistry as a Phase II Chemical Bonding Center, or CBC. CENTC brings together a group of sixteen investigators from across the United States to work on the development of efficient, inexpensive and environmentally friendly methods of synthesizing organic materials by way of activation of strong bonds. New methodology based on using transition metals to selectively activate and functionalize strong chemical bonds has the potential to revolutionize the production of chemicals from large scale bulk processes to fine chemical synthesis, such as occurs in the pharmaceutical industry. A broad scope of projects is being pursued in this Phase II CBC including hydroamination, oxidation, C-H functionalization, alkane metathesis, fuel cell research, the use of biomass as feedstocks and enzymatic chemistry. The work occuring at CENTC is having a broad impact through the training of students at all levels. In addition, high school teachers from various parts of the United States are participating in the center and helping in the production of presentations and videos on the advances and implications of CENTC research. The center has an industrial affiliates program which allows for direct communication of CENTC research results to industry where it can be converted into real-world applications. Projects supported by the center focus on greening -- economically and environmentally -- chemical, petroleum, pharmaceutical and material production and thus have significant potential to increase US competitiveness and to enhance our national security through an increase in energy independence.

Publications Produced as a Result of this Research

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Kundu, S.; Snyder, B. E. R.; Walsh, A. P.; Brennessel, W. W.; Jones, W. D. "C-S Bond Activation of Thioethers Using (dippe)Pt(NBE)2" Polyhedron, v.58, 2013, p.99-105. doi:http://dx.doi.org/10.1016/j.poly.2012.07.071 

Choi, J; Wang, DY; Kundu, S; Choliy, Y; Emge, TJ; Krogh-Jespersen, K; Goldman, AS "Net Oxidative Addition of C(sp(3))-F Bonds to Iridium via Initial C-H Bond Activation" SCIENCE, v.332, 2011, p.1545. doi:10.1126/science.120051  View record at Web of Science

Meredith, JA; Goldberg, KI; Kaminsky, W; Heinekey, DM "Dinuclear Iridium Complexes Containing Cp* and Carbonyl Ligands: Synthesis, Structure, and Reactivity" ORGANOMETALLICS, v.28, 2009, p.3546. doi:10.1021/om900186  View record at Web of Science

Huang, Z; White, PS; Brookhart, M "Ligand exchanges and selective catalytic hydrogenation in molecular single crystals" NATURE, v.465, 2010, p.598. doi:10.1038/nature0908  View record at Web of Science

Kovach, J.; Peralta, M.; Brennessel, W. W.; Jones, W. D. "Synthesis and X-ray Crystallographic Characterization of Substituted Aryl Imines" J. Mol. Struct., v.992, 2011, p.33. doi:10.1016/j.molstruc.2011.02.027 

Huff, CA; Sanford, MS "Cascade Catalysis for the Homogeneous Hydrogenation of CO2 to Methanol" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, 2011, p.18122. doi:10.1021/ja208760  View record at Web of Science

Tanabe, T; Evans, ME; Brennessel, WW; Jones, WD "C-H and C-CN Bond Activation of Acetonitrile and Succinonitrile by [Tp ' Rh(PR3)]" ORGANOMETALLICS, v.30, 2011, p.834. doi:10.1021/om101002  View record at Web of Science

ter Horst, M.; Urbin, S.; Burton, R.; McMillan, C. "Using proton nuclear magnetic resonance as a rapid response research tool for methyl ester characterization in biodiesel" Lipid Technology, v.21, 2009, p.39. doi:10.1002/lite.200900004 

Haibach, M. C.; Kundu, S.; Brookhart, M.; Goldman, A. S. "Alkane Metathesis by Tandem Alkane-Dehydrogenation-Olefin-Metathesis Catalysis and Related Chemistry" Acc. Chem. Res., v.45, 2012, p.947. doi:http://dx.doi.org/10.1021/ar3000713 

Tran, S. D.; Tronic, T. A.; Kaminsky, W.; Heinekey, D. M.; Mayer, J. M. "Metal-free Carbon Dioxide Reduction and Acidic C-H Activation using a Frustrated Lewis Pair" Inorg. Chim. Acta, v.369, 2011, p.126. doi:10.1016/j.ica.2010.12.022 

Matson, TD; Barta, K; Iretskii, AV; Ford, PC "One-Pot Catalytic Conversion of Cellulose and of Woody Biomass Solids to Liquid Fuels" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, 2011, p.14090. doi:10.1021/ja205436  View record at Web of Science

Du, J; Shao, ZY; Zhao, HM "Engineering microbial factories for synthesis of value-added products" JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.38, 2011, p.873. doi:10.1007/s10295-011-0970-  View record at Web of Science

Hanson, SK; Baker, RT; Gordon, JC; Scott, BL; Thorn, DL "Aerobic Oxidation of Lignin Models Using a Base Metal Vanadium Catalyst" INORGANIC CHEMISTRY, v.49, 2010, p.5611. doi:10.1021/ic100528  View record at Web of Science

Nair, N. U.; Denard, C. A.; Zhao, H. "Engineering of Enzymes for Selective Catalysis" Curr. Org. Chem., v.14, 2010, p.1870. doi:10.2174/138527210792927537 

Choi, J; Goldman, AS "Ir-Catalyzed Functionalization of C-H Bonds" IRIDIUM CATALYSIS, v.34, 2011, p.139. doi:10.1007/978-3-642-15334-1_  View record at Web of Science

Look, JL; Wick, DD; Mayer, JM; Goldberg, KI "Autoxidation of Platinum(IV) Hydrocarbyl Hydride Complexes To Form Platinum(IV) Hydrocarbyl Hydroperoxide Complexes" INORGANIC CHEMISTRY, v.48, 2009, p.1356. doi:10.1021/ic801216  View record at Web of Science

Hanson, SK; Heinekey, DM; Goldberg, KI "C-H bond activation by Rhodium(I) phenoxide and acetate complexes: Mechanism of H-D exchange between arenes and water" ORGANOMETALLICS, v.27, 2008, p.1454. doi:10.1021/om701225  View record at Web of Science

Hickman, AJ; Villalobos, JM; Sanford, MS "Quantitative Assay for the Direct Comparison of Platinum Catalysts in Benzene H/D Exchange" ORGANOMETALLICS, v.28, 2009, p.5316. doi:10.1021/om900495  View record at Web of Science

Nair, N., Zhao H. "Evolution in Reverse: Engineering a D-Xylose-specific Xylose Reductase" ChemBioChem, v., 2008, p.. doi:10.1002/cbic.200700765 

Crisci, A. J.; Tucker, M. H.; Dumesic, J. A.; Scott, S. L. "Functionalized periodic mesoporous silica catalysts for the selective dehydration of carbohydrates" Prepr. Pap.-Am. Chem. Soc., Div. Pet. Chem., v.56, 2011, p.148.

Schultz, K. M.; Goldberg, K. I.; Gusev, D. G.; Heinekey, D. M. "Synthesis, Structure and Reactivity of Iridium NHC Pincer Complexes" Organometallics, v.30, 2011, p.1429. doi:10.1021/om101024x 

Li, T.; Jones, W. D. "DFT Calculations of the Isomerization of 2-Methyl-3-butenenitrile by [Ni(bisphosphine)] in Relation to the DuPont Adiponitrile Process" Organometallics, v.30, 2011, p.547. doi:10.1021/om100907y 

Bernskoetter, WH; Schauer, CK; Goldberg, KI; Brookhart, M "Characterization of a Rhodium(I) sigma-Methane Complex in Solution" SCIENCE, v.326, 2009, p.553. doi:10.1126/science.117748  View record at Web of Science

Gladysz, JA; Ball, ZT; Bertrand, G; Blum, SA; Dong, VM; Dorta, R; Hahn, FE; Humphrey, MG; Jones, WD; Klosin, J; Manners, I; Marks, TJ; Mayer, JM; Rieger, B; Ritter, JC; Sattelberger, AP; Schomaker, JM; Yam, VWW "Organometallics Roundtable 2011" ORGANOMETALLICS, v.31, 2012, p.1. doi:10.1021/om201234  View record at Web of Science

Engelman, KL; Feng, YE; Ison, EA "C-H Bond Functionalization of Benzoic Acid: Catalytic Synthesis of 2-Hydroxy-6H-benzo[c]chromen-6-ones Using (Cp*IrCl2)(2)" ORGANOMETALLICS, v.30, 2011, p.4572. doi:10.1021/om200343  View record at Web of Science

Li, L; Jiao, YZ; Brennessel, WW; Jones, WD "Reactivity and Regioselectivity of Insertion of Unsaturated Molecules into M-C (M = Ir, Rh) Bonds of Cyclometalated Complexes" ORGANOMETALLICS, v.29, 2010, p.4593. doi:10.1021/om100796  View record at Web of Science

Williams, DB; Kaminsky, W; Mayer, JM; Goldberg, KI "Reactions of iridium hydride pincer complexes with dioxygen: new dioxygen complexes and reversible O-2 binding" CHEMICAL COMMUNICATIONS, v., 2008, p.4195. doi:10.1039/b802739  View record at Web of Science

Boisvert, L.; Goldberg, K. I. "Reactions of Late Transition Metal Complexes with Molecular Oxygen" Acc. Chem. Res., v.45, 2012, p.899. doi:http://dx.doi.org/10.1021/ar2003072 

Bezier, D., Park, S., Brookhart, M. "Selective Reduction of Carboxylic Acids To Aldehydes catalyzed by B(C6F5)3" Organic Letters, v.15, 2013, p.496-499. doi:http://dx.doi.org/10.1021/ol303296a 

Pagan-Torres, Y. J.; Wang, T.; Gallo, J. M. R.; Shanks, B. H.; Dumesic, J. A. "Production of 5-Hydroxymethylfurfural from Glucose Using a Combination of Lewis and Bronsted Acid Catalysts in Water in a Biphasic Reactor with an Alkylphenol Solvent" ACS Catalysis, v.2, 2012, p.930. doi:http://dx.doi.org/10.1021/cs300192z 

Huang, Z.; Rolfe, E.; Carson, E. C.; Brookhart, M.; Goldman, A. S.; El-Khalafy, S. H.; MacArthur, A. H. R. "Efficient Heterogeneous Dual Catalyst Systems for Alkane Metathesis" Adv. Synth. Catal., v.352, 2010, p.125. doi:10.1002/adsc.200900539 

Huang, Z; Rolfe, E; Carson, EC; Brookhart, M; Goldman, AS; El-Khalafy, SH; MacArthur, AHR "Efficient Heterogeneous Dual Catalyst Systems for Alkane Metathesis" ADVANCED SYNTHESIS & CATALYSIS, v.352, 2010, p.125. doi:10.1002/adsc.20090053  View record at Web of Science

Evans, ME; Li, T; Jones, WD "C-H vs C-C Bond Activation of Acetonitrile and Benzonitrile via Oxidative Addition: Rhodium vs Nickel and Cp* vs Tp ' (Tp ' = Hydrotris(3,5-dimethylpyrazol-1-yl)borate, Cp* = eta(5)-Pentamethylcyclopentadienyl)" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, 2010, p.16278. doi:10.1021/ja107927  View record at Web of Science

Schultz, KM; Goldberg, KI; Gusev, DG; Heinekey, DM "Synthesis, Structure, and Reactivity of Iridium NHC Pincer Complexes" ORGANOMETALLICS, v.30, 2011, p.1429. doi:10.1021/om101024  View record at Web of Science

Ke, Z.; Cundari, T.R. "Palladium-Catalyzed C-H Activation/C-N Bond Formation Reactions: DFT Study of Reaction Mechanisms and Reactive Intermediates" Organometallics, v.29, 2010, p.821. doi:10.1021/om900895t 

Ke, ZF; Cundari, TR "Palladium-Catalyzed C-H Activation/C-N Bond Formation Reactions: DFT Study of Reaction Mechanisms and Reactive Intermediates" ORGANOMETALLICS, v.29, 2010, p.821. doi:10.1021/om900895  View record at Web of Science

Ahuja, R; Punji, B; Findlater, M; Supplee, C; Schinski, W; Brookhart, M; Goldman, AS "Catalytic dehydroaromatization of n-alkanes by pincer-ligated iridium complexes" NATURE CHEMISTRY, v.3, 2011, p.167. doi:10.1038/NCHEM.94  View record at Web of Science

Hartwig, H. J. "Hydrocarbon synthesis: Ringing the Chains" Nature Chemistry, v.3, 2011, p.99. doi:10.1038/nchem.978 

Huang, Z; Brookhart, M; Goldman, AS; Kundu, S; Ray, A; Scott, SL; Vicente, BC "Highly Active and Recyclable Heterogeneous Iridium Pincer Catalysts for Transfer Dehydrogenation of Alkanes" ADVANCED SYNTHESIS & CATALYSIS, v.351, 2009, p.188. doi:10.1002/adsc.20080061  View record at Web of Science

Hanley, Patrick S.; Marquard, Seth L.; Cundari, Thomas R.; Hartwig, John F. "Reductive Elimination of Alkylamines from Low-Valent, Alkylpalladium(II) Amido Complexes" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, 2012, p.15281-152.

Kovach, J; Peralta, M; Brennessel, WW; Jones, WD "Synthesis and X-ray crystallographic characterization of substituted aryl imines" JOURNAL OF MOLECULAR STRUCTURE, v.992, 2011, p.33. doi:10.1016/j.molstruc.2011.02.02  View record at Web of Science

Nair, NU; Zhao, HM "Evolution in reverse: Engineering a D-xylose-specific xylose reductase" CHEMBIOCHEM, v.9, 2008, p.1213. doi:10.1002/cbic.20070076  View record at Web of Science

Choi, J.; MacArthur, A.; Brookhart, M.; Goldman, A. S. "Dehydrogenation and Related Reactions Catalyzed by Iridium Pincer Complexes" Chem. Rev., v.111, 2011, p.1761. doi:10.1021/cr1003503 

Goldman, A. S.; Brookhart, M.; Huang, Z.; Krogh-Jespersen, K.; Kundu, S.; Scott, S. L. "Transition-metal-based catalytic systems for the dehydrogenation and metathesis of alkanes. Solution-phase and solid-supported iridium-based pincer catalysts" Prepr. Symp. - Am. Chem. Soc., Div. Fuel Chem., v.54, 2009, p.213.

Wang, M.; Si, T.; Zhao, H. "Biocatalyst development by directed evolution" Bioresource Technology, v.115, 2012, p.117. doi:http://dx.doi.org/10.1016/j.biortech.2012.01.054 

O'Connor, AR; Kaminsky, W; Heinekey, DM; Goldberg, KI "Synthesis, Characterization, and Reactivity of Arene-Stabilized Rhodium Complexes" ORGANOMETALLICS, v.30, 2011, p.2105. doi:10.1021/om100947  View record at Web of Science

Hanson, SK; Baker, RT; Gordon, JC; Scott, BL; Silks, LA; Thorn, DL "Mechanism of Alcohol Oxidation by Dipicolinate Vanadium(V): Unexpected Role of Pyridine" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, 2010, p.17804. doi:10.1021/ja105739  View record at Web of Science

Emmert, MH; Cook, AK; Xie, YJ; Sanford, M "Remarkably High Reactivity of Pd(OAc)(2)/Pyridine Catalysts: Nondirected C-H Oxygenation of Arenes" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.50, 2011, p.9409. doi:10.1002/anie.20110332  View record at Web of Science

Warren, J. J.; Tronic, T. A.; Mayer, J. M. "Thermochemistry of Proton-Coupled Electron Transfer Reagents and its Implications" Chem. Rev., v.110, 2010, p.6961. doi:10.1021/cr100085k 

Hanson, SK; Baker, RT; Gordon, JC; Scott, BL; Sutton, AD; Thorn, DL "Aerobic Oxidation of Pinacol by Vanadium(V) Dipicolinate Complexes: Evidence for Reduction to Vanadium(III)" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, 2009, p.428. doi:10.1021/ja807522  View record at Web of Science

Vicente, BC; Nelson, RC; Moses, AW; Chattopadhyay, S; Scott, SL "Interactions Involving Lewis Acidic Aluminum Sites in Oxide-Supported Perrhenate Catalysts" JOURNAL OF PHYSICAL CHEMISTRY C, v.115, 2011, p.9012. doi:10.1021/jp109929  View record at Web of Science

O'Connor, A. R.; Kaminsky, W.; Heinekey, D. M.; Goldberg, K. I. "Synthesis, Characterization, and Reactivity of Arene-Stabilized Rhodium Complexes" Organometallics, v.30, 2011, p.2105. doi:10.1021/om1009473 

Crisci, AJ; Tucker, MH; Dumesic, JA; Scott, SL "Bifunctional Solid Catalysts for the Selective Conversion of Fructose to 5-Hydroxymethylfurfural" TOPICS IN CATALYSIS, v.53, 2010, p.1185. doi:10.1007/s11244-010-9560-  View record at Web of Science

Vicente, B. C.; Huang, Z.; Brookhart, M.; Goldman, A. S.; Scott, S. L. "Reactions of phosphinites with oxide surfaces: a new method for anchoring organic and organometallic complexes" Dalton Trans., v.40, 2011, p.4268. doi:10.1039/C0DT01369B 

Kovach, J.; Brennessel, W. W.; Jones, W. D. "Synthesis and Characterization of Cationic Rhodium(I) Dicarbonyl Complexes" Inorg. Chim. Acta, v.367, 2011, p.108. doi:10.1016/j.ica.2010.12.005 

Lyons, Thomas W.; Guironnet, Damien; Findlater, Michael; Brookhart, Maurice "Synthesis of p-Xylene from Ethylene" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, 2012, p.15708-157.

Cheng, Chen; Brookhart, Maurice "Efficient Reduction of Esters to Aldehydes through Iridium-Catalyzed Hydrosilylation" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.51, 2012, p.9422-9424.

Ahuja, R.; Punji, B.; Findlater, M.; Supplee, C.; Schinski, W.; Brookhart, M.; Goldman, A. S. "Catalytic Dehydroaromatization of n-Alkanes by Pincer-Ligated Iridium Complexes" Nature Chemistry, v.3, 2011, p.167. doi:10.1038/nchem.946 

Waidmann, C. R.; Miller, A. J. M.; Ng, C.-W.A.; Scheuermann, M. L.; Porter, T. R.; Tronic, T. A.; Mayer, J. M. "Using Combinations of Oxidants and Bases as PCET Reactants: Thermochemical and Practical Considerations" Energy Envir. Sci., v.5, 2012, p.7771. doi:http://dx.doi.org/10.1039/c2ee03300c 

Findlater, M.; Bernskoetter, W. H.; Brookhart, M. "Proton-Catalyzed Hydrogenation of a d8 Ir(I) Complex Yields a trans Ir(III) Dihydride" J. Am. Chem. Soc., v.132, 2010, p.4534. doi:10.1021/ja100168w 

Findlater, M; Bernskoetter, WH; Brookhart, M "Proton-Catalyzed Hydrogenation of a d(8) Ir(I) Complex Yields a trans Ir(III) Dihydride" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, 2010, p.4534. doi:10.1021/ja100168  View record at Web of Science

Schrauben, J. N.; Hayoun, R.; Valdez, C. N.; Braten, M.; Fridley, L.; Mayer, J. M. "Titanium and Zinc Oxide Nanoparticles Are Proton-Coupled Electron Transfer Agents" Science, v.336, 2012, p.1298. doi:http://dx.doi.org/10.1126/science.1220234 

Meredith, JM; Robinson, R; Goldberg, KI; Kaminsky, W; Heinekey, DM "C-H Bond Activation by Cationic Iridium(III) NHC Complexes: A Combined Experimental and Computational Study" ORGANOMETALLICS, v.31, 2012, p.1879. doi:10.1021/om201216  View record at Web of Science

Hartwig, JF "HYDROCARBON SYNTHESIS Ringing the chains" NATURE CHEMISTRY, v.3, 2011, p.99. doi:10.1038/nchem.97  View record at Web of Science

Li, L.; Jiao, Y.; Brennessel, W. W.; Jones, W. D. "Reactivity and Regioselectivity of Insertion of Unsaturated Molecules into M-C (M = Ir, Rh) Bonds of Cylometallated Complexes" Organometallics, v.29, 2010, p.4593. doi:10.1021/om100796q 

Vicente, B. C.; Nelson, R. C.; Singh, J.; Scott, S. L.; van Bokhoven, J. A. "Electronic structures of supported Pt and PtSn nanoparticles in the presence of adsorbates and during CO oxidation" Catalysis Today, v.160, 2011, p.137. doi:10.1016/j.cattod.2010.07.017 

Liang, J.; Luo, Y.; Zhao, H. "Synthetic Biology: Put Synthesis in Biology" Wiley Interdisciplinary Reviews: Systems Biology and Medicine, v.3, 2011, p.7. doi:10.1002/wsbm.104 

Macala, G. S.; Robertson, A. W.; Johnson, C. L.; Day, Z. B.; Lewis, R. S.; White, M. G.; Iretskii, A. V.; Ford, Peter C. "Transesterification Catalysts from Iron Doped Hydrotalcite-like Precursors: Solid Bases for Biodiesel Production" Catalysis Letters, v.122, 2008, p.205. doi:10.1007/s10562-008-9480-y 

Vicente, BC; Nelson, RC; Singh, J; Scott, SL; van Bokhoven, JA "Electronic structures of supported Pt and PtSn nanoparticles in the presence of adsorbates and during CO oxidation" CATALYSIS TODAY, v.160, 2011, p.137. doi:10.1016/j.cattod.2010.07.01  View record at Web of Science

Ahuja, R; Kundu, S; Goldman, AS; Brookhart, M; Vicente, BC; Scott, SL "Catalytic ring expansion, contraction, and metathesis-polymerization of cycloalkanes" CHEMICAL COMMUNICATIONS, v., 2008, p.253. doi:10.1039/b712197  View record at Web of Science

Yuan, J.; Schrock, R. R.; Muller, P.; Axtell, J. C.; Dobereiner, G. E. "Pentafluorophenylimido Alkylidene Complexes of Molybdenum and Tungsten" Organometallics, v.31, 2012, p.4650. doi:http://dx.doi.org/10.1021/om300408n 

Punji, B; Emge, TJ; Goldman, AS "A Highly Stable Adamantyl-Substituted Pincer-Ligated Iridium Catalyst for Alkane Dehydrogenation" ORGANOMETALLICS, v.29, 2010, p.2702. doi:10.1021/om100145  View record at Web of Science

Bernskoetter, WH; Hanson, SK; Buzak, SK; Davis, Z; White, PS; Swartz, R; Goldberg, KI; Brookhart, M "Investigations of Iridium-Mediated Reversible C-H Bond Cleavage: Characterization of a 16-Electron Iridium(III) Methyl Hydride Complex" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, 2009, p.8603. doi:10.1021/ja901706  View record at Web of Science

Goldman, A. S.; Brookhart, M.; Huang, Z.; Krogh-Jesperson, K,; Kundu, S.; Scott, S. L. "Transition-metal-based catalytic systems for the dehydrogenation and metathesis of alkanes. Solution-phase and solid-supported iridium-based pincer catalysts." Prep. Symp. - Am. Chem. Soc., Div. Fuel Chem., v.54, 2009, p.213.

Liang, J; Luo, YZ; Zhao, HM "Synthetic biology: putting synthesis into biology" WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, v.3, 2011, p.7. doi:10.1002/wsbm.10  View record at Web of Science

Crisci, AJ; Tucker, MH; Lee, MY; Jang, SG; Dumesic, JA; Scott, SL "Add-Functionalized SBA-15-Type Silica Catalysts for Carbohydrate Dehydration" ACS CATALYSIS, v.1, 2011, p.719. doi:10.1021/cs200123  View record at Web of Science

Hanson, S. K.; Baker, R. T.; Gordon, J. C.; Scott, B. L.; Silks, L. A. "Pete"; Thorn, D. L. "Mechanism of Alcohol Oxidation by Dipicolinate Vanadium(V): Unexpected Role of Pyridine" J. Am. Chem. Soc., v.132, 2010, p.17804. doi:10.1021/ja105739k 

Barta, K; Matson, TD; Fettig, ML; Scott, SL; Iretskii, AV; Ford, PC "Catalytic disassembly of an organosolv lignin via hydrogen transfer from supercritical methanol" GREEN CHEMISTRY, v.12, 2010, p.1640. doi:10.1039/c0gc00181  View record at Web of Science

Atesin, TA; Kundu, S; Skugrud, K; Lai, KA; Swartz, BD; Li, T; Brennessel, WW; Jones, WD "Predicting Selectivity in Oxidative Addition of C-S Bonds of Substituted Thiophenes to a Platinum(0) Fragment: An Experimental and Theoretical Study" ORGANOMETALLICS, v.30, 2011, p.4578. doi:10.1021/om200352  View record at Web of Science

Yuan, J; Townsend, EM; Schrock, RR; Goldman, AS; Muller, P; Takase, MK "Preparation of Tungsten-Based Olefin Metathesis Catalysts Supported on Alumina" ADVANCED SYNTHESIS & CATALYSIS, v.353, 2011, p.1985. doi:10.1002/adsc.20110020  View record at Web of Science

Rhinehart, JL; Manbeck, KA; Buzak, SK; Lippa, GM; Brennessel, WW; Goldberg, KI; Jones, WD "Catalytic Arene H/D Exchange with Novel Rhodium and Iridium Complexes" ORGANOMETALLICS, v.31, 2012, p.1943. doi:10.1021/om201241  View record at Web of Science

Reithofer, M. R.; Dobereiner, G. E.; Schrock, R. D.; Muller, P. "Monoaryloxide Pyrrolide (MAP) Imido Alkylidene Complexes of Molybdenum and Tungsten That Contain 2,6-Bis(2,5-R2-pyrrolyl)phenoxide (R = i-Pr, Ph) Ligands and an Unsubstituted Metallacyclobutane on Its Way to Losing Ethylene" Organometallics, v.32, 2013, p.2489-2492. doi:http://dx.doi.org/10.1021/om400114h 

Bailey, BC; Schrock, RR; Kundu, S; Goldman, AS; Huang, Z; Brookhart, M "Evaluation of Molybdenum and Tungsten Metathesis Catalysts for Homogeneous Tandem Alkane Metathesis" ORGANOMETALLICS, v.28, 2009, p.355. doi:10.1021/om800877  View record at Web of Science

Remy, M. S.; Cundari, T. R.; Sanford, M. S. "Computational and Experimental Studies of Methyl Group Exchange between Palladium(II) Centers" Organometallics, v.29, 2010, p.1522. doi:10.1021/om901039u 

Remy, MS; Cundari, TR; Sanford, MS "Computational and Experimental Studies of Methyl Group Exchange between Palladium(II) Centers" ORGANOMETALLICS, v.29, 2010, p.1522. doi:10.1021/om901039  View record at Web of Science

Hanson, SK; Wu, RL; Silks, LA "C-C or C-O Bond Cleavage in a Phenolic Lignin Model Compound: Selectivity Depends on Vanadium Catalyst" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.51, 2012, p.3410. doi:10.1002/anie.20110702  View record at Web of Science

Grochowski, MR; Brennessel, WW; Jones, WD "Dinuclear Ir(III) Complex with an Unusual eta(1):eta(3)-allylic Bridging Ligand from the Double C-H Activation of 2,5-Dimethylthiophene" JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, v.41, 2011, p.829. doi:10.1007/s10870-011-0006-  View record at Web of Science

Kundu, S; Brennessel, WW; Jones, WD "Synthesis and Reactivity of New Ni, Pd, and Pt 2,6-Bis(di-tert-butylphosphinito)pyridine Pincer Complexes" INORGANIC CHEMISTRY, v.50, 2011, p.9443. doi:10.1021/ic201102  View record at Web of Science

Marquard, SL; Hartwig, JF "C(sp(3))-O Bond-Forming Reductive Elimination of Ethers from Bisphosphine-Ligated Benzylpalladium(II) Aryloxide Complexes" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.50, 2011, p.7119. doi:10.1002/anie.20110108  View record at Web of Science

Ahmed Foskey, T. J.; Heinekey, D. M.; Goldberg, K. I. "Partial Deoxygenation of 1,2 Propanediol Catalyzed by Iridium Pincer Complexes" ACS Catalysis, v.2, 2012, p.1285. doi:http://dx.doi.org/10.1021/cs300120d 

Tran, SD; Tronic, TA; Kaminsky, W; Heinekey, DM; Mayer, JM "Metal-free carbon dioxide reduction and acidic C-H activations using a frustrated Lewis pair" INORGANICA CHIMICA ACTA, v.369, 2011, p.126. doi:10.1016/j.ica.2010.12.02  View record at Web of Science

Li, T; Jones, WD "DFT Calculations of the Isomerization of 2-Methyl-3-butenenitrile by [Ni(bisphosphine)] in Relation to the DuPont Adiponitrile Process" ORGANOMETALLICS, v.30, 2011, p.547. doi:10.1021/om100907  View record at Web of Science

Findlater, M; Schultz, KM; Bernskoetter, WH; Cartwright-Sykes, A; Heinekey, DM; Brookhart, M "Dihydrogen Complexes of Iridium and Rhodium" INORGANIC CHEMISTRY, v.51, 2012, p.4672. doi:10.1021/ic202630  View record at Web of Science

Warren, JJ; Tronic, TA; Mayer, JM "Thermochemistry of Proton-Coupled Electron Transfer Reagents and its Implications" CHEMICAL REVIEWS, v.110, 2010, p.6961. doi:10.1021/cr100085  View record at Web of Science

Huff, C. A.; Kampf, J. W.; Sanford, M. S. "Role of a Noninnocent Pincer Ligand in the Activation of CO2 at (PNN)Ru(H)(CO)" Organometallics, v.31, 2012, p.4643. doi:http://dx.doi.org/10.1021/om300403b 

Feng, Y; Jiang, B; Boyle, PA; Ison, EA "Effect of Ancillary Ligands and Solvents on H/D Exchange Reactions Catalyzed by Cp*Ir Complexes" ORGANOMETALLICS, v.29, 2010, p.2857. doi:10.1021/om100018  View record at Web of Science

Macala, GS; Matson, TD; Johnson, CL; Lewis, RS; Iretskii, AV; Ford, PC "Hydrogen Transfer from Supercritical Methanol over a Solid Base Catalyst: A Model for Lignin Depolymerization" CHEMSUSCHEM, v.2, 2009, p.215. doi:10.1002/cssc.20090003  View record at Web of Science

Alamillo, R; Tucker, M; Chia, M; Pagan-Torres, Y; Dumesic, J "The selective hydrogenation of biomass-derived 5-hydroxymethylfurfural using heterogeneous catalysts" GREEN CHEMISTRY, v.14, 2012, p.1413. doi:10.1039/c2gc35039  View record at Web of Science

Villalobos, J. M.; Hickman, A. J.; Sanford, M. S. "Platinum(II) Complexes Containing Quaternized Nitrogen Ligands: Synthesis, Stability, and Evaluation as Catalysts for Methane and Benzene H/D Exchange" Organometallics, v.29, 2010, p.257. doi:10.1021/om900889k 

Villalobos, JM; Hickman, AJ; Sanford, MS "Platinum(II) Complexes Containing Quaternized Nitrogen Ligands: Synthesis, Stability, and Evaluation as Catalysts for Methane and Benzene H/D Exchange" ORGANOMETALLICS, v.29, 2010, p.257. doi:10.1021/om900889  View record at Web of Science

Sedai, B; Diaz-Urrutia, C; Baker, RT; Wu, RL; Silks, LA; Hanson, SK "Comparison of Copper and Vanadium Homogeneous Catalysts for Aerobic Oxidation of Lignin Models" ACS CATALYSIS, v.1, 2011, p.794. doi:10.1021/cs200149  View record at Web of Science

Nair, NU; Zhao, HM "Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars" METABOLIC ENGINEERING, v.12, 2010, p.462. doi:10.1016/j.ymben.2010.04.00  View record at Web of Science

Marquard, S. L.; Rosenfeld, D. C.; Hartwig, J. F. "C(sp3)-N Bond-Forming Reductive Elimination of Amines: Reactions of Bisphosphine-Ligated Benzylpalladium(II) Diarylamido Complexes" Angew. Chem. Int. Ed. Eng., v.49, 2010, p.793. doi:10.1002/anie.200904032 

Marquard, SL; Rosenfeld, DC; Hartwig, JF "C(sp(3))-N Bond-Forming Reductive Elimination of Amines: Reactions of Bisphosphine-Ligated Benzylpalladium(II) Diarylamido Complexes" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.49, 2010, p.793. doi:10.1002/anie.20090403  View record at Web of Science

Kundu, S; Brennessel, WW; Jones, WD "C-S Bond Activation of Thioesters Using Platinum(0)" ORGANOMETALLICS, v.30, 2011, p.5147. doi:10.1021/om200452  View record at Web of Science

Findlater, M; Cartwright-Sykes, A; White, PS; Schauer, CK; Brookhart, M "Role of Coordination Geometry in Dictating the Barrier to Hydride Migration in d(6) Square-Pyramidal Iridium and Rhodium Pincer Complexes" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, 2011, p.12274. doi:10.1021/ja204851  View record at Web of Science

ter Horst, M.; Urbin, S.; Burton, R.; McMillan, C. "Using proton nuclear magnetic resonance as a rapid response research tool for methyl ester characterization of biodiesel" Lipid Technology, v.21, 2009, p.39. doi:10.1002/lite.20090004 

er Horst, M.; Urbin, S.; Burton, R.; McMillan, C. "Using proton nuclear magnetic resonance as a rapid response research tool for methyl ester characterization of biodiesel" Lipid Technology, v.21, 2009, p.39. doi:10.1002/lite.20090004 

Kundu, S; Choliy, Y; Zhuo, G; Ahuja, R; Emge, TJ; Warmuth, R; Brookhart, M; Krogh-Jespersen, K; Goldman, AS "Rational Design and Synthesis of Highly Active Pincer-Iridium Catalysts for Alkane Dehydrogenation" ORGANOMETALLICS, v.28, 2009, p.5432. doi:10.1021/om900568  View record at Web of Science

Cobb, Ryan E.; Chao, Ran; Zhao, Huimin "Directed Evolution: Past, Present, and Future" AICHE JOURNAL, v.59, 2013, p.1432-1440.

Tan, Y.; Hartwig, J. F. "Palladium-Catalyzed Amination of Aromatic C-H Bonds with Oxime Esters" J. Am. Chem. Soc., v.132, 2010, p.3676. doi:10.1021/ja100676r 

Tan, YC; Hartwig, JF "Palladium-Catalyzed Amination of Aromatic C-H Bonds with Oxime Esters" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, 2010, p.3676. doi:10.1021/ja100676  View record at Web of Science

Lanci, MP; Remy, MS; Kaminsky, W; Mayer, JM; Sanford, MS "Oxidatively Induced Reductive Elimination from ((t)Bu(2)bpy)Pd(Me)(2): Palladium(IV) Intermediates in a One-Electron Oxidation Reaction" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, 2009, p.15618. doi:10.1021/ja905816  View record at Web of Science

Kovach, J; Brennessel, WW; Jones, WD "Synthesis and characterization of cationic rhodium(I) dicarbonyl complexes" INORGANICA CHIMICA ACTA, v.367, 2011, p.108. doi:10.1016/j.ica.2010.12.00  View record at Web of Science

Macala, GS; Robertson, AW; Johnson, CL; Day, ZB; Lewis, RS; White, MG; Iretskii, AV; Ford, PC "Transesterification catalysts from iron doped hydrotalcite-like precursors: Solid bases for biodiesel production" CATALYSIS LETTERS, v.122, 2008, p.205. doi:10.1007/s10562-008-9480-  View record at Web of Science

Grochowski, MR; Morris, J; Brennessel, WW; Jones, WD "C-CN Bond Activation of Benzonitrile with [Rh-1(dippe)](-)" ORGANOMETALLICS, v.30, 2011, p.5604. doi:10.1021/om200342  View record at Web of Science

Kundu, S; Brennessel, WW; Jones, WD "Making M-CN bonds from M-Cl in (PONOP)M and (dippe)Ni systems (M = Ni, Pd, and Pt) using t-BuNC" INORGANICA CHIMICA ACTA, v.379, 2011, p.109. doi:10.1016/j.ica.2011.09.04  View record at Web of Science

Kubota, A; Emmert, MH; Sanford, MS "Pyridine Ligands as Promoters in Pd-II/0-Catalyzed C-H Olefination Reactions" ORGANIC LETTERS, v.14, 2012, p.1760. doi:10.1021/ol300281  View record at Web of Science

Choi, J; MacArthur, AHR; Brookhart, M; Goldman, AS "Dehydrogenation and Related Reactions Catalyzed by Iridium Pincer Complexes" CHEMICAL REVIEWS, v.111, 2011, p.1761. doi:10.1021/cr100350  View record at Web of Science

Emmert, MH; Gary, JB; Villalobos, JM; Sanford, MS "Platinum and Palladium Complexes Containing Cationic Ligands as Catalysts for Arene H/D Exchange and Oxidation" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.49, 2010, p.5884. doi:10.1002/anie.20100235  View record at Web of Science

Evans, M. E.; Li, T.; Jones, W. D. "C-H vs. C-C Bond Activation of Acetonitrile and Benzonitrile via Oxidative Addition: Rhodium vs. Nickel and Cp* vs. Tp' (Tp' = hydrotris(3,5-dimethylpyrazol-1-yl)borate, Cp* = η5-pentamethylcyclopentadienyl)" J. Am. Chem. Soc., v.132, 2010, p.16278. doi:10.1021/ja107927b 

Nair, NU; Denard, CA; Zhao, HM "Engineering of Enzymes for Selective Catalysis" CURRENT ORGANIC CHEMISTRY, v.14, 2010, p.1870. View record at Web of Science

Wigington, B. M.; Drummond, M. L.; Cundari, T. R.; Thorn, D. L.; Hanson, S. K.; Scott, S. L. " "A Biomimetic Pathway for Vanadium-Catalyzed Aerobic Oxidation of Alcohols: Evidence for a Base-Assisted Dehydrogenation Mechanism" Chem. Eur. J., v.18, 2012, p.14981-149. doi:http://dx.doi.org/10.1002/chem.201202499 

Lanci, MP; Remy, MS; Lao, DB; Sanford, MS; Mayer, JM "Modulating Sterics in Trimethylplatinum(IV) Diimine Complexes To Achieve C-C Bond-Forming Reductive Elimination" ORGANOMETALLICS, v.30, 2011, p.3704. doi:10.1021/om200508  View record at Web of Science

Kang, P; Cheng, C; Chen, ZF; Schauer, CK; Meyer, TJ; Brookhart, M "Selective Electrocatalytic Reduction of CO2 to Formate by Water-Stable Iridium Dihydride Pincer Complexes" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, 2012, p.5500. doi:10.1021/ja300543  View record at Web of Science

Foley, NA; Ke, ZF; Gunnoe, TB; Cundari, TR; Petersen, JL "Aromatic C-H activation and catalytic hydrophenylation of ethylene by TpRu{P(OCH2)(3)CEt}(NCMe)Ph" ORGANOMETALLICS, v.27, 2008, p.3007. doi:10.1021/om800275  View record at Web of Science

Vicente, BC; Huang, Z; Brookhart, M; Goldman, AS; Scott, SL "Reactions of phosphinites with oxide surfaces: a new method for anchoring organic and organometallic complexes" DALTON TRANSACTIONS, v.40, 2011, p.4268. doi:10.1039/c0dt01369  View record at Web of Science

Barnett, SM; Goldberg, KI; Mayer, JM "A soluble copper-bipyridine water-oxidation electrocatalyst" NATURE CHEMISTRY, v.4, 2012, p.498. doi:10.1038/NCHEM.135  View record at Web of Science

Publications Produced as Conference Proceedings

Ghosh, R;Kundu, S;Choliy, Y;Shariatmadari, A;Lecea, M;Krogh-Jespersen, K;Goldman, AS "INOR 589-Experimental and computational studies of metal-ligand binding energies: Comparison of results obtained using PBE and B3LYP functionals" 235th American-Chemical-Society National Meeting, v.235, 2008, p. View record at Web of Science

Huang, Z;Carson, EC;Brookhart, M;Kundu, S;Goldman, AS "INOR 816-Alkane metathesis with a dual catalysts system and hydrogen transfer with alumina-supported pincer Ir catalyst" 235th American-Chemical-Society National Meeting, v.235, 2008, p. View record at Web of Science

Kundu, S;Goldman, AS;Huang, Z;Brookhart, M "INOR 43-Synthesis and catalytic activity of heterogenized (supported) pincer-ligated iridium catalysts for alkane dehydrogenation." 236th National Meeting of the American-Chemical-Society, v.236, 2008, p. View record at Web of Science

Biswas, S;Ahuja, R;Ray, A;Choliy, Y;Krogh-Jespersen, K;Brookhart, M;Goldman, AS "INOR 302-Transfer dehydrogenation reaction of alkanes: Unusual aspects of selectivity" 235th American-Chemical-Society National Meeting, v.235, 2008, p. View record at Web of Science

Biswas, S;Ahuja, R;Ray, A;Choliy, Y;Krogh-Jespersen, K;Brookhart, M;Goldman, AS "INOR 125-A tale of two ligands. Subtle differences in sterics exert major differences in the energetics of alkane dehydrogenation catalyzed by pincer complexes (tBuPCP)Ir vs. (tBuPOCOP)Ir" 236th National Meeting of the American-Chemical-Society, v.236, 2008, p. View record at Web of Science

Punji, B;Emge, TJ;Goldman, AS "INOR 268-Adamantyl PCP pincer iridium catalyst for the transfer dehydrogenation of alkane" 236th National Meeting of the American-Chemical-Society, v.236, 2008, p. View record at Web of Science

Krogh-Jespersen, K;Choliy, Y;Goldman, AS "PHYS 560-Computational and experimental studies of pincer-ligated Ir complexes relevant to catalysis" 236th National Meeting of the American-Chemical-Society, v.236, 2008, p. View record at Web of Science

Bernskoetter, WH;Brookhart, MS "INOR 583-Mechanistic studies relevant to small molecule activation by iridium bis(phosphinite) pincer complexes" 235th American-Chemical-Society National Meeting, v.235, 2008, p. View record at Web of Science


Project Outcomes Report

Disclaimer

This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.

The Center for Enabling New Technologies through Catalysis (CENTC) was established in 2007 as the first NSF Phase II Center for Chemical Innovation (CCI). Through this award CENTC brought together 19 senior investigators and their graduate students and postdocs from 13 institutions across North America to address collaboratively one of society’s most pressing current needs – the development of new methods for the sustainable production of chemicals and fuels. In particular, CENTC scientists worked on the development of new types of catalysts. Catalysts are added to chemical reactions to accelerate the reactions, to allow the reactions to occur at lower temperatures, and to increase the selectivity of the reaction to form one particular type of product. Catalysts can also be developed to make new reactions possible that allow different starting materials (more readily available, less expensive and less toxic) to be used to make a desired product. Nearly all of the current industrial production of fuels, plastics, drugs and other products rely on catalysts. More efficient catalysts will not only contribute to lower energy use by the chemical and pharmaceutical industry, but will allow us to better utilize our natural resources, lower chemical waste production and move toward a sustainable society. 

Chemists and chemical engineers in CENTC have collaborated on understanding, designing, and developing new catalysts that will allow for more efficient, economic and greener technologies in the chemical industry. At the most fundamental level, CENTC scientists have investigated new reactions for the selective cleavage and formation of C-H, C-C, C-O, O-O and O-H bonds. The knowledge gained has been used to devise innovative methodologies, including novel types of tandem catalytic processes (where two or more catalysts work together to promote a series of reactions), to achieve valuable transformations such as direct alkane functionalization, selective defunctionalization of biomass, utilization of carbon dioxide as a feedstock chemical, and the oxidation of water. In addition to large number of publications in scientific journals reporting these advances, CENTC scientists have been awarded and/or submitted patents on their inventions. CENTC has also initiated a direct connection to industry through our Industrial Affiliates (IA) program. With representatives from energy companies, chemical companies and pharmaceutical companies, our IA program has provided insight into the areas in need of key breakthroughs. The IA program has also provided for opportunities to transform CENTC’s scientific discoveries into practical technologies.

The collaborative approach of CENTC has offered unique training for over 180 undergraduate students, graduate students and postdoctoral researchers. Their experiences with CENTC and their demonstrated ability to work effectively on team projects have helped them to secure their desired employment in industry, government agencies/labs or in academics. 17 CENTC graduate and postdoctoral alumni are now in the U.S. industrial workforce in the fields of chemicals, fuels and pharmaceuticals. CENTC also sponsored "summer schools" in 2008, 2010 and 2013 to educate the greater science community in catalysis. Most of the participants (graduate students, postdoctoral associates, faculty and industrial scientists) were not otherwise associated with CENTC.

CENTC researchers have worked to disseminate information about the role of catalysis in our lives and about CENTC research to a broad segment of the public. Most notably, CENTC has developed content and contributed to a variety of projects and exhibits at prominent science museums across the US. These exhibits educate the public on the large number of products in our daily lives that are made from chemicals originating from oil. Through understanding the role of pet...

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