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Research Spending & Results

Award Detail

Awardee:GEORGIA TECH RESEARCH CORPORATION
Doing Business As Name:Georgia Tech Research Corporation
PD/PI:
  • Nicholas Hud
  • (404) 385-1162
  • hud@chemistry.gatech.edu
Co-PD(s)/co-PI(s):
  • David G Lynn
  • Jean-Marie D Dimandja
  • Jerzy Leszczynski
  • Thomas Orlando
Award Date:08/08/2007
Estimated Total Award Amount: $ NaN
Funds Obligated to Date: $ 1,502,440
  • FY 2007=$750,000
  • FY 2008=$500,000
  • FY 2009=$252,440
Start Date:08/15/2007
End Date:01/31/2011
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.049
Primary Program Source:490100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:CBCI: The Origins Project
Federal Award ID Number:0739189
DUNS ID:097394084
Parent DUNS ID:097394084
Program:CHE CENTERS
Program Officer:
  • Katharine Covert
  • (703) 292-4950
  • kcovert@nsf.gov

Awardee Location

Street:Office of Sponsored Programs
City:Atlanta
State:GA
ZIP:30332-0420
County:Atlanta
Country:US
Awardee Cong. District:05

Primary Place of Performance

Organization Name:Georgia Institute of Technology
Street:225 NORTH AVE NW
City:Atlanta
State:GA
ZIP:30332-0002
County:Atlanta
Country:US
Cong. District:05

Abstract at Time of Award

Nicholas Hud of Georgia Institute of Technology, Jean-Marie Dimandja of Spelman College, Jerzy Leszczynski of Jackson State Univeristy, David Lynn of Emory University and Thomas Orlando of Georgia Tech are supported by an award from the Chemical Bonding Centers (CBC) for a Phase I program to carry out research on the chemical origin of life. The project is based on the theory that life evolved from prebiotic precursors that spontaneously assembled into RNA-like polymers. Questions that are being addressed include: What molecules were potentially present in the prebiotic chemical inventory? What molecules can self-assemble to form RNA-like polymers? And what molecules could have acted as prebiotic catalysts for the formation or assembly of other molecules? There are three principal objectives of the CBC: (i) to determine the potential building blocks of RNA-like polymers and to understand the reactions which form them; (ii) to uncover possible early metabolisms and mechanisms of self-assembly that could have selectively produced and coupled these building blocks into more complex molecules, eventually leading to RNA-like polymers; and (iii) to develop a distributed, cyber-enabled approach to advancing our knowledge of model prebiotic chemical reactions that will involve undergraduate students and their local mentors. The work is having a broad impact in a number of ways: through the participation of women and under-represented minorities, particularly through the HBCU partner institutions of Spelman and Jackson State University; through the development of a high school outreach program that is making prebiotic experiments accessible to high school chemistry teachers; by further developing an existing course on "Chemistry of the Origin of Life" and through a research seminar series for freshmen on the "Origins of Order"; and through plans to disseminate information about the center through radio, local public television, computer graphics, and web-based educational modules.

Publications Produced as a Result of this Research

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Childers, WS; Ni, R; Mehta, AK; Lynn, DG "Peptide membranes in chemical evolution" CURRENT OPINION IN CHEMICAL BIOLOGY, v.13, 2009, p.652. doi:10.1016/j.cbpa.2009.09.02  View record at Web of Science

Yinghong Sheng, Heather D. Bean, Nicholas V. Hud and Jerzy Leszczynski "A Comprehensive Investigation of the Energetics of Pyrimidine Nucleoside Formation under Prebiotic Conditions" J. Am. Chem. Soc., v.131, 2009, p.1.

Childers, WS; Mehta, AK; Ni, R; Taylor, JV; Lynn, DG "Peptides Organized as Bilayer Membranes" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.49, 2010, p.4104. doi:10.1002/anie.20100021  View record at Web of Science

Childers, WS; Lu, K. Mehta, AK; Lynn, DG "Templating Molecular Arrays in Amyloid's Cross-B Grooves" J. Am. Chem. Soc., v.131, 2009, p..

Eric D. Horowitz, Aaron E. Engelhart, Kaycee A. Quarles, Michael W. Smith, David Lynn, and Nicholas V. Hud "Intercalation as a solution to the strand cyclization problem in a pre-RNA world" Proc. Natl. Acad. Sci. USA, v.107, 2010, p..

Childers, WS; Ni, R. Mehta, AK; Lynn, DG "Prebiotic Membranes" Curr. Op. Chem Biol., v.13, 2009, p.652.

Sheng, YH; Bean, HD; Mamajanov, I; Hud, NV; Leszczynski, J "Comprehensive Investigation of the Energetics of Pyrimidine Nucleoside Formation in a Model Prebiotic Reaction" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, 2009, p.16088. doi:10.1021/ja900807  View record at Web of Science

Mamajanov, I; Engelhart, AE; Bean, HD; Hud, NV "DNA and RNA in Anhydrous Media: Duplex, Triplex, and G-Quadruplex Secondary Structures in a Deep Eutectic Solvent" ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.49, 2010, p.6310. doi:10.1002/anie.20100156  View record at Web of Science

Horowitz, ED; Engelhart, AE; Chen, MC; Quarles, KA; Smith, MW; Lynn, DG; Hud, NV "Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, 2010, p.5288. doi:10.1073/pnas.091417210  View record at Web of Science

Barks, HL; Buckley, R; Grieves, GA; Di Mauro, E; Hud, NV; Orlando, TM "Guanine, Adenine, and Hypoxanthine Production in UV-Irradiated Formamide Solutions: Relaxation of the Requirements for Prebiotic Purine Nucleobase Formation" CHEMBIOCHEM, v.11, 2010, p.1240. doi:10.1002/cbic.20100007  View record at Web of Science

Mehta, AK; Lu, K; Childers, WS; Liang, Y; Dublin, S; Dong, J; Snyder, JP; Skanthakumar, S; Thiyagerajan, P; Lynn, DG. "Facial Symmetry in Self-assembly" J. Am. Chem. Soc., v.130, 2008, p.9. doi:10.1021/ja801511n 

Liang, Y.; Gao, P.; Pingali, S.V.; Pabit, S.; Thiyagarajan, P.; Berland, K. M.; Lynn "Light Harvesting Antenna on an Amyloid Scaffold" Chem. Commun., v., 2008, p.6522.

Childers, WS; Mehta, AK; Lu, K; Lynn, DG "Templating Molecular Arrays in Amyloid's Cross-beta Grooves" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, 2009, p.10165. doi:10.1021/ja902332  View record at Web of Science

Liu, P; Ni, R; Mehta, AK; Childers, WS; Lakdawala, A; Pingali, SV; Thiyagarajan, P; Lynn, DG "Nucleobase-Directed Amyloid Nanotube Assembly" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.130, 2008, p.16867. doi:10.1021/ja807425  View record at Web of Science

Hud, N. V. "Nucleotide Adsorption on Mineral Surfaces- A Mixed Blessing for the RNA World?" Astrobiology, v.9, 2009, p.253.

Liang, Y.; Pingali, S.V.; Jogalekar, A.S.; Snyder, J.P.; Thiyagarajan, P.; Lynn, D.G. "Cross-strand Pairing and Amyloid Assembly" Biochemistry, v.47, 2008, p.10018.

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