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Minimize RSR Award Detail

Research Spending & Results

Award Detail

Awardee:UNIVERSITY OF KENTUCKY
Doing Business As Name:University of Kentucky Research Foundation
PD/PI:
  • Brad J Berron
  • (859) 257-2791
  • brad.berron@uky.edu
Award Date:08/30/2019
Estimated Total Award Amount: $ 106,662
Funds Obligated to Date: $ 106,662
  • FY 2019=$106,662
Start Date:09/01/2019
End Date:08/31/2020
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.041
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:NSF/FDA/SIR: Evaluating cellular integrity as a function of bioprinter nozzle geometry
Federal Award ID Number:1935836
DUNS ID:939017877
Parent DUNS ID:007400724
Program:BioP-Biophotonics
Program Officer:
  • Leon Esterowitz
  • (703) 292-7942
  • lesterow@nsf.gov

Awardee Location

Street:109 Kinkead Hall
City:Lexington
State:KY
ZIP:40526-0001
County:Lexington
Country:US
Awardee Cong. District:06

Primary Place of Performance

Organization Name:University of Kentucky Research Foundation
Street:500 S. Limestone
City:Lexington
State:KY
ZIP:40526-0001
County:Lexington
Country:US
Cong. District:06

Abstract at Time of Award

"Bioprinting" is an approach to assemble individual living cells to form tissue like skin or muscle, much like 3-D printing with metal or plastic to form machine parts. This method promises to revolutionize fabrication of tissue replacements or tissue models for drug testing. A limitation of bioprinting is that individual cells are fragile and may be damaged by being squirted through a narrow tube called a capillary through a small opening. The project proposes to measure damage to the cell membrane, internal skeleton, and DNA depending on the properties of the printing capillary. The applicants propose to address an important issue in "bioprinting", which is like 3D printing to assemble cells into tissue like skin or muscle. The issue is that the shear forces in the narrow capillary in the print head can damage the cell membrane, cytoskeleton, and DNA in the nucleus; slowing the liquid flow in the capillary to reduce the shear force may result in an unacceptable reduction in print speed. The applicants propose to determine the effects of shear time and changes in capillary properties on the cell damage. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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