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Research Spending & Results

Award Detail

Doing Business As Name:University of Utah
  • Kenneth L Monson
  • (801) 585-5191
Award Date:07/08/2020
Estimated Total Award Amount: $ 568,663
Funds Obligated to Date: $ 568,663
  • FY 2020=$568,663
Start Date:08/15/2020
End Date:07/31/2023
Transaction Type:Grant
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.041
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:Defining Multiscale, Rate-Dependent Damage Mechanisms in Blood Vessels
Federal Award ID Number:2027367
DUNS ID:009095365
Parent DUNS ID:009095365
Program:BMMB-Biomech & Mechanobiology
Program Officer:
  • Laurel Kuxhaus
  • (703) 292-4465

Awardee Location

Street:75 S 2000 E
County:Salt Lake City
Awardee Cong. District:02

Primary Place of Performance

Organization Name:University of Utah
County:Salt Lake City
Cong. District:02

Abstract at Time of Award

Blood vessels can be damaged as a result of large shape changes – deformations – that occur in both accidents (such as traumatic brain injury) and surgery (such as angioplasty). However, little is known about how this damage affects a vessel’s ability to continue to perform its function. This is especially true when damage is subtle and there is no bleeding. Additionally, recent research shows that the rate of deformation influences the type of resulting damage. The goals of this project are to define damage mechanisms in blood vessels and to define how damage changes vessel function. The project focuses on blood vessels in the brain. The results of this project will provide insight about damage mechanisms in traumatic brain injury, and may eventually lead to better healthcare treatments. This information will improve design criteria for automobiles, helmets, and other protective devices. It may also reveal factors that increase the risk of stroke after brain injury. It may also improve outcomes of balloon angioplasty procedures. Researchers involved in this project will include students from underrepresented groups, who will gain valuable professional development. The aims of this project are (1) to differentiate and quantify contributions of both recoverable (e.g. viscoelasticity) and non-recoverable (e.g. collagen unfolding) mechanisms of vessel softening, and (2) to define the influence of strain rate on mechanisms of damage. Microstructural damage and associated softening will be defined using isolated blood vessels subjected to overstretch through a range of strain rates. Experimental findings will be incorporated into a novel constitutive model that relates multiscale damage of passive vessel constituents with mechanical behavior. This is a critical first step toward predicting disease development and/or recovery after injury. While the research focuses on blood vessels, findings are expected to also apply to other soft tissues. Results will advance injury prevention strategies and provide a foundation for optimization of design for both interventional procedures and implantable biomaterials and devices. These experiments will inform computer models that predict damage-induced changes in vessel behavior. Finally, the research will further develop methods for characterizing soft tissue damage, including collagen hybridizing peptide to quantify collagen damage. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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