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Research Spending & Results

Award Detail

Awardee:OREGON STATE UNIVERSITY
Doing Business As Name:Oregon State University
PD/PI:
  • Christopher Cebra
  • (541) 737-5568
  • chris.cebra@oregonstate.edu
Award Date:08/13/2020
Estimated Total Award Amount: $ 50,000
Funds Obligated to Date: $ 50,000
  • FY 2020=$50,000
Start Date:08/01/2020
End Date:01/31/2021
Transaction Type:Grant
Agency:NSF
Awarding Agency Code:4900
Funding Agency Code:4900
CFDA Number:47.041
Primary Program Source:040100 NSF RESEARCH & RELATED ACTIVIT
Award Title or Description:I-Corps: Single-domain antibody platform to develop cancer immunotherapies for the treatment of both canine and human cancers
Federal Award ID Number:2040609
DUNS ID:053599908
Parent DUNS ID:053599908
Program:I-Corps
Program Officer:
  • Ruth Shuman
  • (703) 292-2160
  • rshuman@nsf.gov

Awardee Location

Street:OREGON STATE UNIVERSITY
City:Corvallis
State:OR
ZIP:97331-8507
County:Corvallis
Country:US
Awardee Cong. District:04

Primary Place of Performance

Organization Name:Oregon State University
Street:1500 Jefferson Way
City:Corvallis
State:OR
ZIP:97331-8507
County:Corvallis
Country:US
Cong. District:04

Abstract at Time of Award

The broader impact/commercialization potential of this I-Corps project is the development and translation of a drug discovery platform for the treatment of both canine and human cancers. The proposed technology defines the requirements for harnessing the ability of immune-based cancer therapies to target and eradicate cancer with a drug platform that may be manipulated to create new and powerful therapies. Developing immune-based cancer therapies may result in the production of a number of cost effective and safe treatments that may be easily administered to patients, potentially making a significant commercial impact. The proposed technology is expected to translate the understanding of cancer progression using the dog as an animal model for clinical investigations. This approach would be a first for canine therapies and is expected to impact development of human cancer therapeutics. This I-Corps project is based on the development of a single-domain antibody platform to develop cancer immunotherapies for the treatment of both canine and human cancers. Cancer immunotherapies based on a single-domain antibody platform have yet to be approved for human use and the development of the proposed canine agents may provide valuable insight into the pharmacologic behavior of this type of agent in the appropriate disease setting. In addition, physically combining single-domain antibodies with other cancer treatment agents, may add a novel way immune molecules may be used to fight cancer growth. The proposed technology has the potential to result in tailored cancer therapies for patients of all types. Thus, this advancement of the state-of-the-art has the potential to quickly bring novel, effective products to all cancer-patients, with marked potential for high commercial and societal impact. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

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